Kidney

Transperitoneal administration of hydrogen suppress peritoneal and systemic oxidative stress

Oxidative Damage Helps Cause Diabetes

Both types of diabetics display increased levels of reactive oxygen species such as free radicals; for this reason, the onset of diabetes is closely associated with oxidative stress (R).

Damaged protein is a contributing factor to the mechanism by which oxidative stress accelerates diabetes complications (R).

Additionally, it appears that oxidative stress byproducts contribute to insulin resistance, the basis of diabetes (R).

Oxidative stress causes an excessive formation of free radicals which weaken defense mechanisms against further oxidation and that increases the likelihood of more cell damage, insulin resistance, and further complications of diabetes (R).

Also, recent research has demonstrated a direct link between the imbalance of oxidative stress and antioxidants leading to impaired glucose uptake (R).

Kidney

Oxidative stress (OS) related to glucose degradation products such as methylglyoxal is reportedly associated with peritoneal deterioration in patients treated with peritoneal dialysis (PD). However, the use of general antioxidant agents is limited due to their harmful effects. This study aimed to clarify the influence of the novel antioxidant molecular hydrogen (H2) on peritoneal OS using albumin redox state as a marker. Effluent and blood samples of 6 regular PD patients were obtained during the peritoneal equilibrium test using standard dialysate and hydrogen-enriched dialysate. The redox state of albumin in effluent and blood was determined using high-performance liquid chromatography. Mean proportion of reduced albumin (ƒ(HMA)) in effluent was significantly higher in H2-enriched dialysate (62.31 ± 11.10%) than in standard dialysate (54.70 ± 13.08%). Likewise, serum ƒ(HMA) after administration of hydrogen-enriched dialysate (65.75 ± 7.52%) was significantly higher than that after standard dialysate (62.44 ± 7.66%). Trans-peritoneal administration of H2 reduces peritoneal and systemic OS.

Link to Full Text

Terawaki H, Hayashi Y, Zhu WJ, Matsuyama Y, Terada T, Kabayama S, et al. Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity. Med Gas Res. 2013 Jul 1;3(1):14.

Hydrogen-rich water in patients with interstitial cystitis and painful bladder syndrome

Kidney-2

The objective of this study was to investigate the efficacy of hydrogen-rich water for the treatment of patients with interstitial cystitis/painful bladder syndrome (IC/PBS). Authors conducted a prospective, randomized, double-blind, placebo-controlled clinical trial of hydrogen-rich water in patients with IC/PBS. Inclusion criteria were stable symptoms of IC/PBS for ≥ 12 weeks after bladder hydrodistension, Interstitial Cystitis Symptom Index score of ≥ 7 and bladder pain (question 4 on Interstitial Cystitis Symptom Index) of ≥ 4. They were randomized by a 2:1 ratio to receive hydrogen-rich water or placebo water for 8 weeks. The symptoms were assessed using the Interstitial Cystitis Symptom Index, Interstitial Cystitis Problem Index, Parsons’ Pelvic Pain and Urgency/Frequency Patient Symptom Scale, visual analog scale bladder pain scores, and a standard 3-day voiding diary. The primary outcome was improvement of patient-reported symptoms evaluated after treatment. A total of 30 participants (29 women and 1 man, age 64.0 ± 14.8 years) were enrolled in the present study, and 2 patients (both women) were withdrawn from the study. The score of bladder pain was significantly reduced in both groups. However, the effect of hydrogen-rich water on symptoms was not significantly different from that of placebo, although supplementation with hydrogen-rich water was extremely effective in improving the bladder pain score in 11% of the patients. The results of the present study do not support the use of supplementation with hydrogen-rich water for treating patients with IC/PBS.

Link to Full Text

Matsumoto S, Ueda T, Kakizaki H. Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome. Urology. 2013;81:226-30.

Adding molecular hydrogen to haemodialysis solutions ameliorated inflammatory reactions

Kidney-1

Chronic inflammation in haemodialysis (HD) patients indicates a poor prognosis. However, therapeutic approaches are limited. Hydrogen gas (H(2)) ameliorates oxidative and inflammatory injuries to organs in animal models. We developed an HD system using a dialysis solution with high levels of dissolved H(2) and examined the clinical effects. Dialysis solution with H(2) (average of 48 ppb) was produced by mixing dialysate concentrates and reverse osmosis water containing dissolved H(2) generated by a water electrolysis technique. Subjects comprised 21 stable patients on standard HD who were switched to the test HD for 6 months at three sessions a week. During the study period, no adverse clinical signs or symptoms were observed. A significant decrease in systolic blood pressure (SBP) before and after dialysis was observed during the study, and a significant number of patients achieved SBP <140 mmHg after HD (baseline, 21%; 6 months, 62%; P < 0.05). Changes in dialysis parameters were minimal, while significant decreases in levels of plasma monocyte chemoattractant protein 1 (P < 0.01) and myeloperoxidase (P < 0.05) were identified. Adding H(2) to haemodialysis solutions ameliorated inflammatory reactions and improved BP control. This system could offer a novel therapeutic option for control of uraemia.

Link to Full Text

Nakayama M, Nakano H, Hamada H, Itami N, Nakazawa R, Ito S. A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial. Nephrol Dial Transplant. 2010;25:3026-33.

Other Medical Research. .

Nakayama, M., et al., Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study. Sci Rep, 2018. 8(1): p. 254.
Hosgood, S.A., et al., Hydrogen Gas Does Not Ameliorate Renal Ischemia Reperfusion Injury in a Preclinical Model. Artif Organs, 2018.
Cheng, T.C., et al., Nephroprotective effect of electrolyzed reduced water against cisplatin-induced kidney toxicity and oxidative damage in mice. J Chin Med Assoc, 2018. 81(2): p. 119-126.
Xing, Z., et al., Hydrogen Rich Water Attenuates Renal Injury and Fibrosis by Regulation Transforming Growth Factor-beta Induced Sirt1. Biol Pharm Bull, 2017. 40(5): p. 610-615.
Nakayama, M., et al., Dissolved molecular hydrogen (H2) in Peritoneal Dialysis (PD) solutions preserves mesothelial cells and peritoneal membrane integrity. BMC Nephrol, 2017. 18(1): p. 327.
Chen, J., et al., Hydrogen-Rich Saline Alleviates Kidney Fibrosis Following AKI and Retains Klotho Expression. Front Pharmacol, 2017. 8: p. 499.
Maeda, K., et al., Improvement of the fraction of human mercaptalbumin on hemodialysis treatment using hydrogen-dissolved hemodialysis fluid: a prospective observational study. Renal Replacement Therapy, 2016. 2(1): p. 42.
Li, J., et al., Hydrogen-Rich Saline Promotes the Recovery of Renal Function after Ischemia/Reperfusion Injury in Rats via Anti-apoptosis and Anti-inflammation. Front Pharmacol, 2016. 7: p. 106.
Du, H., et al., Hydrogen-Rich Saline Attenuates Acute Kidney Injury After Liver Transplantation via Activating p53-Mediated Autophagy. Transplantation, 2016. 100(3): p. 563-70.
Terawaki, H., et al., Successful treatment of encapsulating peritoneal sclerosis by hemodialysis and peritoneal lavage using dialysate containing dissolved hydrogen. Perit Dial Int, 2015. 35(1): p. 107-12.
Tange, Y., S. Takesawa, and S. Yoshitake, Dialysate with high dissolved hydrogen facilitates dissociation of indoxyl sulfate from albumin. Nephrourol Mon, 2015. 7(2): p. e26847.
Peng, Z., et al., Inhalation of hydrogen gas ameliorates glyoxylate-induced calcium oxalate deposition and renal oxidative stress in mice. Int J Clin Exp Pathol, 2015. 8(3): p. 2680-9.
Homma, K., et al., Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats. Nephron Exp Nephrol, 2015.
Guo, S.X., et al., Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation. J Transl Med, 2015. 13: p. 183.
Xin, H.G., et al., Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats. Mol Cell Biochem, 2014. 392(1-2): p. 117-24.
Terawaki, H., et al., Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients. Hemodial Int, 2014. 18(2): p. 459-66.
Liu, W., et al., A novel fluid resuscitation protocol: provide more protection on acute kidney injury during septic shock in rats. Int J Clin Exp Med, 2014. 7(4): p. 919-26.
Gu, H., et al., Pretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis and acute kidney injury in rats. J Surg Res, 2014. 188(1): p. 243-9.
Zhu, W.J., et al., Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water. Med Gas Res, 2013. 3(1): p. 26.
Kato, S., et al., Colloidal platinum in hydrogen-rich water exhibits radical-scavenging activity and improves blood fluidity. J Nanosci Nanotechnol, 2012. 12(5): p. 4019-27.
Katakura, M., et al., Hydrogen-rich water inhibits glucose and alpha,beta -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney. Medical Gas Research, 2012. 2(1): p. 18.
Abe, T., et al., Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury. Transplantation, 2012. 94(1): p. 14-21.
Matsushita, T., et al., Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging. Magn Reson Med Sci, 2011. 10(3): p. 169-76.
Nakayama, M., et al., A novel bioactive haemodialysis system using dissolved dihydrogen (H-2) produced by water electrolysis: a clinical trial. Nephrology Dialysis Transplantation, 2010. 25(9): p. 3026-3033.
Kitamura, A., et al., Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT. British Journal of Radiology, 2010. 83(990): p. 509-514.
Huang, K.C., et al., Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic haemodialysis. Nephrology Dialysis Transplantation, 2010. 25(8): p. 2730-2737.
Cardinal, J.S., et al., Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney International, 2010. 77(2): p. 101-9.
Nakayama, M., et al., Biological Effects of Electrolyzed Water in Hemodialysis. Nephron Clinical Practice, 2009. 112(1): p. C9-C15.
Ohaski, Y., et al., Electrolyzed water reduces urinary protein excretion in the streptozotocin induced diabetic Dahl salt sensitive rats. The FASEB Journal, 2008. 22: p. 947.17.
Nakayama, M., et al., Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water. Hemodial Int, 2007. 11(3): p. 322-7.
Yeung, L.K., et al., Effect of electrolyzed reduced water hemodialysis on peripheral lymphocyte intracellular cytokine expression. Nephrology Dialysis Transplantation, 2006. 21: p. 204-204.
Huang, K.C., et al., Electrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients. Kidney Int, 2006. 70(2): p. 391-8.
Huang, K.C., et al., Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water. Kidney Int, 2003. 64(2): p. 704-14.
Abe, T., et al., Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury. Transplantation, 2012. 94(1): p. 14-21.
Abe, T., et al., Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury.Transplantation, 2012. 94(1): p. 14-21.
Cardinal, J.S., et al., Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney International, 2010. 77(2): p. 101-9.
Homma, K., et al., Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats. Nephron Exp Nephrol, 2015.
Gu, H., et al., Pretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis and acute kidney injury in rats. J Surg Res, 2014. 188(1): p. 243-9.
Kato, S., et al., Colloidal platinum in hydrogen-rich water exhibits radical-scavenging activity and improves blood fluidity. J Nanosci Nanotechnol, 2012. 12(5): p. 4019-27.
Kitamura, A., et al., Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT. British Journal of Radiology, 2010. 83(990): p. 509-514.
Liu, W., et al., A novel fluid resuscitation protocol: provide more protection on acute kidney injury during septic shock in rats. Int J Clin Exp Med, 2014. 7(4): p. 919-26.
Matsushita, T., et al., Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging. Magn Reson Med Sci, 2011. 10(3): p. 169-76.
Nakayama, M., et al., Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water. Hemodial Int, 2007. 11(3): p. 322-7.
Ohaski, Y., et al., Electrolyzed water reduces urinary protein excretion in the streptozotocin induced diabetic Dahl salt sensitive rats. The FASEB Journal, 2008. 22: p. 947.17.
Terawaki, H., et al., Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients.Hemodial Int, 2014. 18(2): p. 459-66.
Terawaki, H., et al., Successful treatment of encapsulating peritoneal sclerosis by hemodialysis and peritoneal lavage using dialysate containing dissolved hydrogen. Perit Dial Int, 2015. 35(1): p. 107-12.
Xin, H.G., et al., Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats. Mol Cell Biochem, 2014. 392(1-2): p. 117-24.
Zhu, W.J., et al., Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water. Med Gas Res, 2013. 3(1): p. 26.

Source :- Kidney – eimht.com

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Kidney

Transperitoneal administration of hydrogen suppress peritoneal and systemic oxidative stress

Oxidative Damage Helps Cause Diabetes

Both types of diabetics display increased levels of reactive oxygen species such as free radicals; for this reason, the onset of diabetes is closely associated with oxidative stress (R).

Damaged protein is a contributing factor to the mechanism by which oxidative stress accelerates diabetes complications (R).

Additionally, it appears that oxidative stress byproducts contribute to insulin resistance, the basis of diabetes (R).

Oxidative stress causes an excessive formation of free radicals which weaken defense mechanisms against further oxidation and that increases the likelihood of more cell damage, insulin resistance, and further complications of diabetes (R).

Also, recent research has demonstrated a direct link between the imbalance of oxidative stress and antioxidants leading to impaired glucose uptake (R).

Link to Full Text

Terawaki H, Hayashi Y, Zhu WJ, Matsuyama Y, Terada T, Kabayama S, et al. Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity. Med Gas Res. 2013 Jul 1;3(1):14.

Hydrogen-rich water in patients with interstitial cystitis and painful bladder syndrome

Link to Full Text

Matsumoto S, Ueda T, Kakizaki H. Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome. Urology. 2013;81:226-30.

Adding molecular hydrogen to haemodialysis solutions ameliorated inflammatory reactions

Link to Full Text

Nakayama M, Nakano H, Hamada H, Itami N, Nakazawa R, Ito S. A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial. Nephrol Dial Transplant. 2010;25:3026-33.

Other Medical Research. .

Nakayama, M., et al., Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study. Sci Rep, 2018. 8(1): p. 254.

Hosgood, S.A., et al., Hydrogen Gas Does Not Ameliorate Renal Ischemia Reperfusion Injury in a Preclinical Model. Artif Organs, 2018.

Cheng, T.C., et al., Nephroprotective effect of electrolyzed reduced water against cisplatin-induced kidney toxicity and oxidative damage in mice. J Chin Med Assoc, 2018. 81(2): p. 119-126.

Xing, Z., et al., Hydrogen Rich Water Attenuates Renal Injury and Fibrosis by Regulation Transforming Growth Factor-beta Induced Sirt1. Biol Pharm Bull, 2017. 40(5): p. 610-615.

Nakayama, M., et al., Dissolved molecular hydrogen (H2) in Peritoneal Dialysis (PD) solutions preserves mesothelial cells and peritoneal membrane integrity. BMC Nephrol, 2017. 18(1): p. 327.

Chen, J., et al., Hydrogen-Rich Saline Alleviates Kidney Fibrosis Following AKI and Retains Klotho Expression. Front Pharmacol, 2017. 8: p. 499.

Maeda, K., et al., Improvement of the fraction of human mercaptalbumin on hemodialysis treatment using hydrogen-dissolved hemodialysis fluid: a prospective observational study. Renal Replacement Therapy, 2016. 2(1): p. 42.

Li, J., et al., Hydrogen-Rich Saline Promotes the Recovery of Renal Function after Ischemia/Reperfusion Injury in Rats via Anti-apoptosis and Anti-inflammation. Front Pharmacol, 2016. 7: p. 106.

Du, H., et al., Hydrogen-Rich Saline Attenuates Acute Kidney Injury After Liver Transplantation via Activating p53-Mediated Autophagy. Transplantation, 2016. 100(3): p. 563-70.

Terawaki, H., et al., Successful treatment of encapsulating peritoneal sclerosis by hemodialysis and peritoneal lavage using dialysate containing dissolved hydrogen. Perit Dial Int, 2015. 35(1): p. 107-12.

Tange, Y., S. Takesawa, and S. Yoshitake, Dialysate with high dissolved hydrogen facilitates dissociation of indoxyl sulfate from albumin. Nephrourol Mon, 2015. 7(2): p. e26847.

Peng, Z., et al., Inhalation of hydrogen gas ameliorates glyoxylate-induced calcium oxalate deposition and renal oxidative stress in mice. Int J Clin Exp Pathol, 2015. 8(3): p. 2680-9.

Homma, K., et al., Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats. Nephron Exp Nephrol, 2015.

Guo, S.X., et al., Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation. J Transl Med, 2015. 13: p. 183.

Xin, H.G., et al., Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats. Mol Cell Biochem, 2014. 392(1-2): p. 117-24.

Terawaki, H., et al., Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients. Hemodial Int, 2014. 18(2): p. 459-66.

Liu, W., et al., A novel fluid resuscitation protocol: provide more protection on acute kidney injury during septic shock in rats. Int J Clin Exp Med, 2014. 7(4): p. 919-26.

Gu, H., et al., Pretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis and acute kidney injury in rats. J Surg Res, 2014. 188(1): p. 243-9.

Zhu, W.J., et al., Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water. Med Gas Res, 2013. 3(1): p. 26.

Kato, S., et al., Colloidal platinum in hydrogen-rich water exhibits radical-scavenging activity and improves blood fluidity. J Nanosci Nanotechnol, 2012. 12(5): p. 4019-27.

Katakura, M., et al., Hydrogen-rich water inhibits glucose and alpha,beta -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney. Medical Gas Research, 2012. 2(1): p. 18.

Abe, T., et al., Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury. Transplantation, 2012. 94(1): p. 14-21.

Matsushita, T., et al., Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging. Magn Reson Med Sci, 2011. 10(3): p. 169-76.

Nakayama, M., et al., A novel bioactive haemodialysis system using dissolved dihydrogen (H-2) produced by water electrolysis: a clinical trial. Nephrology Dialysis Transplantation, 2010. 25(9): p. 3026-3033.

Kitamura, A., et al., Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT. British Journal of Radiology, 2010. 83(990): p. 509-514.

Huang, K.C., et al., Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic haemodialysis. Nephrology Dialysis Transplantation, 2010. 25(8): p. 2730-2737.

Cardinal, J.S., et al., Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney International, 2010. 77(2): p. 101-9.

Nakayama, M., et al., Biological Effects of Electrolyzed Water in Hemodialysis. Nephron Clinical Practice, 2009. 112(1): p. C9-C15.

Ohaski, Y., et al., Electrolyzed water reduces urinary protein excretion in the streptozotocin induced diabetic Dahl salt sensitive rats. The FASEB Journal, 2008. 22: p. 947.17.

Nakayama, M., et al., Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water. Hemodial Int, 2007. 11(3): p. 322-7.

Yeung, L.K., et al., Effect of electrolyzed reduced water hemodialysis on peripheral lymphocyte intracellular cytokine expression. Nephrology Dialysis Transplantation, 2006. 21: p. 204-204.

Huang, K.C., et al., Electrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients. Kidney Int, 2006. 70(2): p. 391-8.

Huang, K.C., et al., Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water. Kidney Int, 2003. 64(2): p. 704-14.

Abe, T., et al., Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury. Transplantation, 2012. 94(1): p. 14-21.

Abe, T., et al., Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury.Transplantation, 2012. 94(1): p. 14-21.

Cardinal, J.S., et al., Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney International, 2010. 77(2): p. 101-9.

Homma, K., et al., Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats. Nephron Exp Nephrol, 2015.

Gu, H., et al., Pretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis and acute kidney injury in rats. J Surg Res, 2014. 188(1): p. 243-9.

Kato, S., et al., Colloidal platinum in hydrogen-rich water exhibits radical-scavenging activity and improves blood fluidity. J Nanosci Nanotechnol, 2012. 12(5): p. 4019-27.

Kitamura, A., et al., Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT. British Journal of Radiology, 2010. 83(990): p. 509-514.

Liu, W., et al., A novel fluid resuscitation protocol: provide more protection on acute kidney injury during septic shock in rats. Int J Clin Exp Med, 2014. 7(4): p. 919-26.

Matsushita, T., et al., Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging. Magn Reson Med Sci, 2011. 10(3): p. 169-76.

Nakayama, M., et al., Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water. Hemodial Int, 2007. 11(3): p. 322-7.

Ohaski, Y., et al., Electrolyzed water reduces urinary protein excretion in the streptozotocin induced diabetic Dahl salt sensitive rats. The FASEB Journal, 2008. 22: p. 947.17.

Terawaki, H., et al., Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients.Hemodial Int, 2014. 18(2): p. 459-66.

Terawaki, H., et al., Successful treatment of encapsulating peritoneal sclerosis by hemodialysis and peritoneal lavage using dialysate containing dissolved hydrogen. Perit Dial Int, 2015. 35(1): p. 107-12.

Xin, H.G., et al., Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats. Mol Cell Biochem, 2014. 392(1-2): p. 117-24.

Zhu, W.J., et al., Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water. Med Gas Res, 2013. 3(1): p. 26.

Source :- Kidney – eimht.com

Disclaimer:

Site contains images from the Google. All images are used for informational or educational purposes only. If you claim copyright to any of these images, please contact us and we will remove it.